Role of Aegle Marmelos Extract in the Management of Haemorrhoids As Compared With Daflon: A Randomized, Active Controlled, Multicentric Study

Abstract

Objective: To evaluate the efficacy of a herbal preparation, Aegle marmelos (AM)Extract with Daflonin in haemorrhoids.
Methodology: Adouble blind, multicentric comparative clinical randomized trial was conducted with acute
haemorrhoids cases divided into two equal and parallel groups (70 each) for one week through randomly selected general physicians in Lahore urban community.
Interventions: Administration of 2 capsules of AM extract twice a day for a week or Daflon (500 mg) in a dose of 6 tablets per day for the first 4 days, followed by 4 tablets per day upto one week. Main outcome measures: Measurable relief in symptoms and signs and patient tolerance.
Results: Characteristics at baseline were near about similar between the two groups. The clinical severity of inflammation, congestion, tenesmus, hematochezia and oedema diminished in both groups, but more quicker in the AME group by the end of 24 hours. Symptoms improved in both groups from day 1 to day 7. Acceptability was good in both groups. No adverse effect was noted in both groups during and at the end of trial.
Conclusion: Both AM extract and Daflon were found equally effective in resolving clinical picture of haemorrhoids.However AM extract acted more quickly.
Keywords: Aegle Marmelos Extract, Daflon, Hemorrhoids